Endocrine Abstracts

Objective: Immune checkpoint inhibitors (ICPI) have become an effective therapeutic option for certain advanced malignant tumours. Immune-related adverse events affecting thyroid function are among the most frequent toxicities. The aim of our study is to determine the prevalence of thyroid disorders in patients undergoing treatment with ICPI.Methods: Retrospective study including all patients treated with ICPI in our centre, from 07/2015 to 12/2017. Pati...

Introduction: Diabetic retinopathy (DR) is the most common microvascular complication in patients with type 1 diabetes (T1D), and the role of lipids in the development of this complication is still controversial. In this study we have analyzed the association between lipid levels at onset and during the follow-up and the subsequent development of DR.Methods: The cohort consists of 1132 patients with T1D who were diagnosed in Navarra between 1/1/1990 and ...

Objectives: The gestations in patients with type 1 diabetes are associated with an increase in maternal-fetal complications. Adequate glycemic control during pregnancy has been shown to reduce adverse events. Given that, the treatment with insulin pump improves glycemic control and that pregnancy implies constant changes in insulin resistance, our objective is to analyze the changes in insulin requirements in pregnant patients under CSII.Materials and me...

Introduction: The aim of our study was to evaluate the causes of thyrotoxicosis detected during pregnancy as well as to determine the prevalence of thyroid nodular disease (TND) in our population and which factors are associated with this condition.Methods: We performed a retrospective review of 1,760 patients between April 2014 and September 2017 remitted from the gynecology department due to thyroid dysfunction detected in the 9th week of pr...

Objetive: The aim of our study is to asses the validity of ultrasound patterns proposed by the ATA and malignancy risk in the cytological diagnosis classified by the Bethesda System.Methods: Prospective study including all thyroid nodules (with no previous cytological results), assessed in our center from July/2016 to June/2017. We classified nodules in ATA sonographic risk patterns and follow-up its fine needle aspiration (FNA) recommendations. The stat...

Objective: The aim of this study is to evaluate clinical characteristics of patients diagnosed of follicular thyroid carcinoma and to study factors that are associated with a worse prognosis of the disease.Methods: We included 153 patients diagnosed of follicular thyroid carcinoma in our centre between January 1985 and December 2016. The baseline characteristics of the patients, and their long-term outcomes were collected. The mean follow-up was 15.2 yea...

Introduction: Asymptomatic, mild or moderate elevations of creatine phosphokinase are frequently found in hypothyroidism, but rhabdomyolysis is rare, and even more so when it constitutes its clinical presentation.Clinical case: A 26-year-old male who regularly practiced sports, with no family or personal history of interest, went to the emergency room referring to myalgia, generalized cramps, and muscular weakness in the previous two weeks which had not ...